Brain Hypoxia and Ischemia

Brain Hypoxia and Ischemia



Gabriel G. Haddad, Shan Ping Yu, Brain Hypoxia and Ischemia
Humana Press | 2008-12-12 | ISBN: 1603275789 | 268 pages | PDF | 5,65 MB

This volume focuses on the mechanisms of cell injury and cell survival in the brain, with special emphasis on development and early life, in relation to hypoxia and ischemia in the brain. The major reason for the emphasis placed on the developmental stages of the brain is the major societal and economic burden of the affliction when it occurs in early life.

Brain hypoxia and ischemia, as a major condition, is not only be devastating, but has the ability to span the age spectrum. For example, stroke, as caused by hypoxia and ischemia, is still a major killer in both the US and the rest of the world irrespective of the etiology or whether it occurs in the young or old. Birth asphyxia and cerebral palsy can be crippling throughout life. Periventricular leukomalacia is still a major consequence of premature birth and can have major long-term consequences.

The book addresses a number of active and cutting edge research ideas by leaders in this field. For example: 1) role of mitochondria; 2) role of ROS; 3) role of hypoxia vs ischemia vs insult paradigm; 4) cell fate in the penumbra; 5) cellular and molecular mechanisms in resistant organisms; 6) role of HIF vs non-HIF-dependent mechanisms; 7) role of ion channels and exchangers; 8) vessel development in early life and prematurity.

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